Description
PE-22-28 10mg — Spadin-Derived Neuropeptide Research Compound
PE-22-28 is a synthetic peptide fragment derived from spadin, studied in research into TREK-1 potassium channel modulation and antidepressant-mechanism pathways. Peptalix Labs supplies PE-22-28 10mg at a verified purity of 99.72%, independently confirmed by Freedom Diagnostics, with a negative fentanyl screen. GMP-sourced, white lyophilised powder. Fast USA same-day shipping with delivery to Canada, Australia, the UK and Europe.
Certificate of Analysis
Every PE-22-28 10mg vial is independently batch-tested by Freedom Diagnostics. COA Accession #2606120656 (reported 06/15/2026) confirmed purity at 99.72% with net peptide content of 9.64mg per vial, Lot 129-01-SM. Download full COA here.
Research Background
PE-22-28 research centres on TREK-1 channel inhibition and proposed antidepressant-mechanism pathways, building on spadin research literature. Frequently studied alongside other cognitive compounds such as Semax and Selank in broader neuropeptide research panels.
Product Specifications
- Product
- PE-22-28 10mg
- Peptide Class
- Spadin-Derived Neuropeptide Fragment
- Appearance
- White Lyophilised Powder
- Fentanyl Screen
- Negative
- Purity
- 99.72% (HPLC-UV + Mass Spectrometry)
- Net Peptide Content
- 9.64 mg per vial
- Lot Number
- 129-01-SM
- COA Accession #
- 2606120656
- Testing Lab
- Freedom Diagnostics
- Reported Date
- 06/15/2026
- Storage
- Lyophilised: -20C. Reconstituted: 2-8C, use within 28 days
- Shipping
- USA same-day. Canada, Australia, UK, Europe
- Research Use
- In-vitro laboratory research only
Reconstitution Guide
Reconstitute using sterile bacteriostatic water. Inject slowly down the inner wall of the vial and gently swirl until dissolved. Never shake. Store reconstituted solution at 2-8C and use within 28 days.
Shipping
Same-day USA dispatch before daily cut-off Monday to Friday. International delivery to Canada, Australia, UK and Europe in 5-12 business days.
Related Cognitive Research Compounds
- Semax 10mg — ACTH(4-10) Analogue Cognitive Peptide
- Selank 10mg — Tuftsin Analogue Cognitive Peptide
- Pinealon 10mg — Neuroprotective Peptide Research
- DSIP 10mg — Delta Sleep-Inducing Peptide
- Selank + Semax Blend 20mg — Dual-Pathway Research Stack
Scientific References
- Telegdy & Schally — PE-22-28 spadin receptor research (PubMed)
- NIH NLM — TREK-1 / Spadin neuropeptide research
- ClinicalTrials.gov — Search: PE-22-28 Research
Research Use Only. Not FDA-approved for human consumption, veterinary use or clinical application. View Certificate of Analysis.
Frequently Asked Questions
What is PE-22-28 peptide?
PE-22-28 is a synthetic peptide fragment derived from spadin, studied in research examining TREK-1 potassium channel modulation and antidepressant-mechanism pathways. Peptalix Labs supplies PE-22-28 10mg at 99.72% purity, confirmed by Freedom Diagnostics.
What purity is Peptalix Labs PE-22-28 10mg?
Independently batch-tested at 99.72% purity by Freedom Diagnostics using HPLC-UV and mass spectrometry. Net content 9.64mg per vial, Lot 129-01-SM, Accession #2606120656, with a negative fentanyl screen.
What does PE-22-28 stand for?
PE-22-28 refers to a specific peptide fragment (residues 22-28) derived from the spadin protein, a TREK-1 channel inhibitor studied in neuropeptide and antidepressant-mechanism research.
How is PE-22-28 peptide stored?
Supplied as white lyophilised powder. Store the sealed vial at -20C prior to reconstitution. Once reconstituted with bacteriostatic water, store at 2-8C and use within 28 days.
How do I reconstitute PE-22-28 10mg?
Draw the desired volume of sterile bacteriostatic water into a fresh syringe and inject slowly down the inner wall of the vial. Gently swirl until fully dissolved. Never shake.
What research has been published on PE-22-28?
PE-22-28 has been studied in relation to TREK-1 potassium channel inhibition and its proposed antidepressant-like mechanism in animal models, building on earlier spadin research.
Can I buy PE-22-28 peptide online in the USA?
Yes. Peptalix Labs offers PE-22-28 10mg for purchase online for qualified USA researchers. COA-verified at 99.72% purity, GMP-sourced, same-day shipping.
Does Peptalix Labs ship PE-22-28 internationally?
Yes, to Canada, Australia, the United Kingdom and most of Europe, with tracked delivery in 5-12 business days.
What is a fentanyl screen and why is it on the COA?
A fentanyl screen is a safety-related analytical test confirming the absence of fentanyl contamination in the tested sample. Peptalix Labs’ PE-22-28 batch returned a negative fentanyl screen result.
What is the appearance of PE-22-28 10mg?
White lyophilised freeze-dried powder, as confirmed in the Freedom Diagnostics COA (Lot 129-01-SM).
Is PE-22-28 peptide legal to buy in the USA?
Yes, as a research chemical for qualified researchers conducting in-vitro laboratory studies. Not FDA-approved for human use. Sold strictly for research purposes.
What is the research dosage range for PE-22-28?
Published PE-22-28 research has used varying dosing parameters depending on the study model. Peptalix Labs does not provide dosing guidance, as our products are sold for research use only.
Which lab verified Peptalix Labs PE-22-28 purity?
Freedom Diagnostics, a US-based independent laboratory operated by Principal Chemist Alex Johnson. Accession #2606120656, reported 06/15/2026.
Is PE-22-28 related to TREK-1 channel research?
Yes. PE-22-28 is derived from spadin, a known TREK-1 potassium channel inhibitor, making it relevant to ion-channel and antidepressant-mechanism neuropeptide research.
What other cognitive peptides does Peptalix Labs offer alongside PE-22-28?
Our cognitive category includes Semax, Selank, the Selank + Semax blend, Pinealon, and DSIP — all COA-verified and GMP-sourced.
